AlphaFold3 predictions of the molecular contacts made by a genome-editing enzyme have been used to improve the enzyme’s selectivity for target DNA sequences.

Rerunning tumour evolution in mice shows how cancer develops after DNA damage and reveals that background genetics and acquired mutations interact to shape genome stability and selection. This provides experimental evidence that genetic ancestry has an important role in setting the trajectory of cancer evolution.

A single-cell gene-expression atlas of the fly nerve cord mapped onto its wiring diagram has uncovered a simple shared gene-expression code. The code enables neurons to carry a molecular memory of the order of their birth from a parent cell, and shapes their diversity.

The severity of geomagnetic storms — magnetic disturbances in Earth’s outer atmosphere — is widely understood to reach an upper limit as the strength of the solar wind increases. But this upper limit is an illusion that results from uncertainty in the measurement of solar-wind strength as the true value regresses towards the mean.