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This study reports the structure-based discovery of LC-F2-1, a selective FGFR2 inhibitor that overcomes clinically observed resistance mutations in cancers. Its co-crystal structure with FGFR2V565F reveals how it may restore drug sensitivity.
Converting nitrate-polluted water into ammonia offers a sustainable alternative to the Haber-Bosch process. Here, authors report a catalyst with sp-C~metal bonds that achieves high selectivity and stability at high currents, enabling fertilizer production and water purification.
Dense self-assembled monolayers are vital for functional interfaces, but molecular aggregation and additives can block surface anchoring. Zeng et al. used a weakly binding additive to guide assembly, forming compact layers that improved tandem solar-cell efficiency.
The authors show that the cooperative DNA binding behavior of 36 Paired-like factors is driven by 11 homeodomain residue positions. These mechanistic insights explain the functional consequences of 38 pathogenic missense variants across the Paired-like family.
'Water-enhanced materials usually exhibit tensile strengths of only a few to several tens of megapascals and limited water-induced reinforcement. Here the authors report a water triggered supramolecular polymer composed of cellulose and polymethyl methacrylate that achieves more than a 22-fold improvement in mechanical properties.'
The transmission of plasmids represents a key mechanism for antimicrobial resistance. Here, authors show AcrIE10 inhibits bacterial CRISPR immunity and dynamically regulates self-expression, balancing host immunity and plasmid anti-defense.
Inspired by cellular structures, this study fabricates an organelle-mimetic nanoreactor to realize the simultaneous co-production of H2 and pyruvic acid via directional charge transport and reaction microenvironment regulation.
The authors developed a novel electrodeposition-initiated, self-catalyzed strategy to synthesize 2D amorphous metal-boron mesoporous films. This provides highly efficient and durable catalysts for the oxygen evolution reaction.
Fully connected quantum networks could enable secure communication between all users, but scalable operation with untrusted providers remains challenging. Here, the authors demonstrate a microcomb-driven measurement-device-independent quantum network using integrated photonics over 200-km fibre.
Celangulin V is a widely used biopesticide, however, its biosynthesis remains largely undefined. Here the authors assemble a genome of C. angulatus, elucidate the Celangulin V biosynthesis pathway, and establish bioproduction in S. cerevisiae.
A neural network called SE2PSNet turns simple spin echo NMR data into high-quality pure shift spectra, resolving overlapping signals while preserving the sensitivity and accurate integral information, with broad potential applications.
Raised boulder beaches on Inexpressible Island record extreme storm waves of 4–9 m during the early to mid-Holocene, when reduced Antarctic sea ice and stronger ocean–atmosphere coupling drove wave energy far exceeding present-day levels.
Above reaction barriers, direct pathways usually dominate. State-resolved experiments and quantum dynamical calculations confirm a transient shape resonance in F + HD → HF + D, tracing the process from reactant states through the transition-state region to product states.
The authors report experimental and DFT-computational investigations that reveal the versatile reactivities of cross-conjugated unsaturated iminium-ion intermediates. These undergo cycloadditions with cyclic and linear dienes via both stepwise and concerted pathways, respectively, providing two distinct classes of enantioenriched cycloadducts.
Kidney pathology reports contain rich information that structured assessment does not fully capture. Here, the authors show that large language models extract and standardize it to define reproducible IgA nephropathy subtypes that improve risk prediction and reveal differential treatment responses.
The electrochemical construction of C–N bonds offers a sustainable route to amide synthesis, yet competing reactions that do not form C–N bonds remain unavoidable. Here, the authors report a coupled electrosynthesis strategy that simultaneously produces formamide at both the cathode and anode by recycling byproducts as feedstocks in the counter electrode, achieving nearly 100% selectivity.
Translation initiation is a key control point of gene expression. Here, the authors identify more than 10,000 cap-independent translation initiators in the human transcriptome and show that 3′UTRs promote translation by recruiting initiation factors to overcome inhibitory 5′UTR structures.
Photocatalytic H₂O₂ production is limited not only by severe non-radiative energy losses but also by a fundamental imbalance between proton and electron transfer kinetics. Here, the authors develop a light–heat–proton coupling strategy that exploits dissipated photothermal energy to promote proton dissociation from carboxylic acids, creating a driving force for efficient redox catalysis and H₂O₂ generation.
