This genetic study utilizing the newest available GWAS summary statistics provides evidence on the relationship between cannabis use, cannabis use disorder and a range of psychiatric disorders.

The authors evaluated and integrated compositional and functional microbiota data using fecal samples taken from healthy individuals and multimodal neuroimaging.

The authors investigate first onsets of psychiatric disorders during perimenopause, finding higher incidence rates of major depressive disorder and mania.

De Giorgi and colleagues present a comprehensive analysis of pre-clinical and clinical studies examining the role of glucagon-like peptide-1 receptor agonists in mental disorders.

This research utilized multi-omics data from 1,274 adolescents to identify transdiagnostic biomarkers for neuropsychiatric disorders, employing genome-wide analyses and Mendelian randomization to uncover causal pathways linking immune dysregulation to psychiatric conditions and revealing potential therapeutic targets.

In this study, the authors report the secondary data analysis of cross-country data examining the impact of gender on depression across 24 European countries.

This Comment argues for better consideration of additional factors, such as external validation, real-world feasibility, and clinical utility, to improve the translation of predictive models for relapse prediction in depression.

This research investigated differences in social learning in autism, finding that non-autistic young adults and autistic adolescents were more accurate at inferring preferences of non-autistic adolescents than those of autistic adolescents.

Using normative modeling to measure the interindividual variability of atypical brain functional connectivity in autism, the authors identify heterogeneity at the level of specific connections alongside high convergence at regional and network scales. These findings offer a neurobiological framework for understanding both individual differences and shared clinical features in autism.

Eshetu and collaborators investigated anxiety comorbidity in later life among adults with elevated autistic traits, examining how anxiety symptoms unfold with aging in a large UK community sample.