Watch on YouTube
7/31/2026
Our Mission
Translating dementia research into better care
Co-directed by Drs. Khushboo Verma and Satwant Kumar, advancing Alzheimer's disease and related dementias through biomarkers, brain-systems research, and real-world care pathways.
We treat rigor as a form of compassion: clear endpoints, transparent methods, and results you can cite.
New preprint (under review; not clinical guidance)
Design-induced circularity in Alzheimer biomarker trials and trial-ready cohorts
A methods-focused preprint on enrichment, estimand mismatch, and selection–inference reuse (“double dipping”).
Leadership
Dr. Khushboo Verma & Dr. Satwant Kumar
Co-directors and partners in life and in science, translating dementia research into better care across biomarkers, clinically grounded AI, and real-world care pathways.
Multimodal biomarkers — PET, MRI, and psychometrics for rigorous phenotyping
Clinically grounded AI — building tools that respect evidence, bias, and workflow
Implementation science — turning results into scalable care pathways
Quick start
Core Pillars
From biomarkers to implementation
Three tightly linked programs organize our work—moving us toward a world without dementia, from multimodal biomarkers to implementation in real-world care.
Integrated Biomarkers
Psychometrics, PET, and Cortical Biomarkers
Longitudinal, multimodal modeling of secondary datasets (e.g., OASIS-3) integrating amyloid PET, structural MRI, and psychometrics to quantify continuous dementia severity and trajectories across distributed cortical and subcortical systems.
- •Psychometrics and Aβ-PET jointly stratify clinical dementia severity (AAN 2023; Neurology 100(17_supplement_2):0104).
- •Open-source, multicenter-validated stroke lesion segmentation model supports voxel-based lesion–symptom mapping (Diagnostics 12:2055, 2022).
Care Pathways
Express Dementia Care & Rural Health Equity
Research and implementation framework for closed-loop Express Dementia Care (EDCC) — workflow design, caregiver navigation, and system-level measurement of access and readiness for disease-modifying therapies in rural East Texas.
- •EDCC pilot data evaluating triage loops, time-to-diagnosis, and caregiver outcomes (AAN 2026 abstracts, submitted).
- •Equity analyses quantify infusion-readiness gaps and care barriers for anti-amyloid therapies.
Systems & AI
Systems Neuroscience, AI & Decision Support
Combining primate systems neuroscience with clinically grounded AI, spanning lesion–symptom mapping, physician-scored benchmarks (ExpertMedQA), and BooksMed decision support.
- •International consortium of 21 physicians across 7 countries validated ExpertMedQA / BooksMed (AAN 2024; Neurology 102(7_supplement_1):3830).
- •Inverse-graphics and optogenetic systems neuroscience studies (PNAS 2025; eLife 2022) inform algorithm design for clinical AI.
Methods & modalities
Capabilities built for collaboration
A systems neuroscience foundation with translational methods that scale to real datasets and real clinics—because better measurement is a path to better care.
Multimodal biomarkers
PET and neuropsychological phenotyping with transparent evaluation metrics and clinically interpretable endpoints.
Neuroimaging analytics
Multicenter stroke lesion segmentation supporting voxel-based lesion–symptom mapping and scalable imaging workflows.
Quantitative modeling
Trajectory and severity modeling designed to surface assumptions, uncertainty, and sensitivity to cohort definitions.
Clinically grounded AI
Physician-scored benchmarks (ExpertMedQA) and state-of-the-art performance validation for expert-level clinical queries.
Implementation science
Express Dementia Care (EDCC) workflows, readiness measurement, and equity-focused operational evaluation.
Systems neuroscience
Mechanistic grounding from causal and computational systems neuroscience to inform translational hypotheses and model design.
Collaboration
A collaboration model designed for rigor
Our north star is a world without dementia. We work like an academic lab: clear endpoints, explicit assumptions, and outputs that stand up to review.
01
Scope the scientific question
Define the clinical context, primary endpoint, and success criteria. We align hypotheses with measurement constraints and realistic effect sizes.
02
Data, governance, and methods
Agree on data access, IRB/DUA requirements, and a reproducible analysis plan. We prioritize transparent evaluation and sensitivity analyses.
03
Deliverables you can use
Produce figures, methods text, and artifacts that support abstracts and manuscripts—plus code and documentation when release is feasible.
Prefer citations and traceable claims? We link key statements to relevant publications and abstracts.
Featured Work
Flagship research & implementation projects
Selected projects spanning biomarker science, health disparities, and systems neuroscience—built for measurable impact.
AIclinical decision support
ExpertMedQA & BooksMed Clinical AI
Physician-scored benchmark across seven countries evaluating expert neurology scenarios and what it takes for clinical AI to be trusted in practice.
biomarkerspsychometrics
Psychometrics + Aβ-PET Severity Mapping
OASIS-3 secondary data analysis integrating amyloid PET and neuropsychological testing to model continuous dementia severity and cognitive decline—supporting more precise phenotyping and earlier detection.
strokelesion mapping
Voxel-Based Lesion–Symptom Mapping for Stroke
Open-source, multicenter-validated stroke lesion segmentation (Diagnostics 2022) enabling scalable, reproducible voxel-based lesion–symptom mapping analyses.
care pathwayshealth equity
Express Dementia Care & Anti-Amyloid Equity
Closed-loop EDCC pathway for rapid triage, caregiver navigation, and measurement of readiness and equity for disease-modifying therapies in rural East Texas—designed to extend evidence-based care beyond major centers.
YouTube
Latest videos from The Dementia Doctor
Recent public education videos on dementia care, caregiver support, and communication strategies.
Watch on YouTube
7/28/2026
Chronic Pain and Dementia: Which Pain Medications Hurt YOUR Memory?
Can chronic pain make memory problems and dementia symptoms appear worse? In this video, Dr. Khushboo Verma, The Dementia Doctor, explains how persistent pai…
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7/12/2026
Lewy Body Dementia: 6 Neurologists Missed His Diagnosis
What happens when a person knows something is wrong but the diagnosis is repeatedly missed? In this deeply personal conversation, Mr. Don Kent shares his jou…