Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in disease. This Expert Recommendation article summarizes ferroptosis regulation and mechanisms and provides recommendations to increase the reproducibility and robustness of ferroptosis research.

Membrane contact sites between organelles facilitate the exchange of ions, lipids and metabolites. This Expert Recommendation highlights recent advances in defining the organelle contactome and discusses challenges and future directions in membrane contact site research.

A 2003 study established that oxidative DNA damage can drive cell senescence of mouse fibroblasts, and that culturing these cells in low oxygen enables their immortalization without p53 loss.

This Comment discusses databases dedicated to curating circular RNA (circRNA) information, including expression patterns, processing, interactions, translation and diseases.

Several mechanisms have been described for the release and transport of Hedgehog morphogens. Here, Grobe and Puschmann propose a unified model in which these pathways interact synergistically.

Direct RNA sequencing by the Oxford nanopore technology enabled simultaneous mapping of different RNA modifications on the same RNA molecule and opened new avenues for studying the physiological roles of RNA modifications.

In this Tools of the Trade article, Mercey and Lemaitre (Hamel and Guichard lab) present an actin-labelling probe compatible with ultrastructure expansion microscopy, enabling high-resolution mapping of cellular actin architecture.

The concept of PANoptosis describes the simultaneous activation of pyroptosis, apoptosis and necroptosis. This Comment discusses the evidence supporting this hypothesis and proposes criteria to validate PANoptosis.